Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | PARP1 | P09874 | 13/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21755742 | 0.88 | PARP1 (0.59) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL8564331 | 0.80 | TP53 (0.68) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL13711927 | 0.80 | TP53 (0.59) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL13711924 | 0.79 | PARP1 (0.61) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL29893230 | 0.78 | PARP1 (0.62) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL3339424 | 0.78 | PARP1 (0.62) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL709373 | 0.78 | PARP1 (0.47) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL4521450 | 0.78 | TP53 (0.56) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL13082234 | 0.77 | TP53 (0.68) | TP53PARP1MAP4K4CSF1RMKNK2 | |
| SCHEMBL9415217 | 0.77 | TP53 (0.68) | TP53PARP1MAP4K4CSF1RMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |