Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569397 | 1.00 | EGFR (0.61) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8570045 | 0.87 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6993876 | 0.86 | EGFR (0.72) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6993885 | 0.86 | EGFR (0.72) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8570632 | 0.84 | EGFR (0.56) | EGFRERBB2HPGDHTTDYRK1A | |
| SCHEMBL6999421 | 0.82 | EGFR (0.68) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8314168 | 0.79 | EGFR (0.52) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8314173 | 0.79 | EGFR (0.52) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8317027 | 0.78 | EGFR (0.60) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8317032 | 0.78 | EGFR (0.60) | EGFRERBB2HPGDHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885226-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032881-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |