Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | CTNNB1 | P35222 | 10/20 | 0.55 |
| ▸ | WNT3A | P56704 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460882 | 0.95 | HDAC8 (0.64) | HDAC8HDAC1CTNNB1WNT3ANPC1 | |
| SCHEMBL151368 | 0.85 | HDAC8 (0.68) | HDAC8HDAC1CTNNB1WNT3ANPC1 | |
| SCHEMBL27688476 | 0.85 | HDAC8 (0.68) | HDAC8HDAC1CTNNB1WNT3ANPC1 | |
| SCHEMBL15979734 | 0.84 | CTNNB1 (0.71) | HDAC8HDAC1CTNNB1WNT3ANPC1 | |
| SCHEMBL27707962 | 0.84 | HDAC8 (0.71) | HDAC8HDAC1CTNNB1WNT3ANPC1 | |
| SCHEMBL27703528 | 0.84 | HDAC8 (0.71) | HDAC8HDAC1CTNNB1WNT3ANPC1 | |
| SCHEMBL6626765 | 0.83 | HDAC8 (0.66) | HDAC8HDAC1CTNNB1WNT3ANPC1 | |
| SCHEMBL5311917 | 0.83 | HDAC8 (0.66) | HDAC8HDAC1CTNNB1WNT3ANPC1 | |
| SCHEMBL11703134 | 0.83 | MEN1 (0.53) | HDAC8HDAC1NPC1LMNASMN1; SMN2 | |
| SCHEMBL7380043 | 0.83 | HDAC8 (0.69) | HDAC8HDAC1CTNNB1WNT3ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |