SCHEMBL8569947

SCHEMBL8569947

Cc1noc(N(CNCC(F)(F)c2ccccc2)S(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2)c1C

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 20/20 0.52
EDNRA P25101 18/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8572335 0.81 EDNRA (0.60) EDNRBEDNRA
SCHEMBL8569192 0.81 EDNRA (0.56) EDNRBEDNRA
SCHEMBL8568596 0.78 EDNRA (0.50) EDNRBEDNRA
SCHEMBL6639043 0.77 EDNRA (0.54) EDNRBEDNRA
SCHEMBL8570228 0.77 EDNRA (0.51) EDNRBEDNRA
SCHEMBL6641243 0.77 EDNRA (0.54) EDNRBEDNRA
SCHEMBL8567622 0.75 EDNRA (0.49) EDNRBEDNRA
SCHEMBL7399051 0.74 EDNRB (0.51) EDNRBEDNRA
SCHEMBL6640085 0.73 EDNRA (0.86) EDNRBEDNRA
Hydrochloric Acid SCHEMBL6643084 0.72 EDNRA (0.85) EDNRBEDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5846990-A Substituted biphenyl isoxazole sulfonamides BRISTOL-MYERS SQUIBB CO. (US) 1998-12-08 US claimed
US-5846990-A Substituted biphenyl isoxazole sulfonamides BRISTOL-MYERS SQUIBB CO. (US) 1998-12-08 US disclosed