Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939996 | 0.81 | GAA (0.63) | KDM4EGAAMEN1KMT2AOPRM1 | |
| SCHEMBL6939993 | 0.81 | GAA (0.63) | KDM4EGAAMEN1KMT2AOPRM1 | |
| SCHEMBL8114305 | 0.81 | GAA (0.63) | KDM4EGAAMEN1KMT2AOPRM1 | |
| SCHEMBL6990992 | 0.76 | GRIN2B (0.59) | GRIN1GRIN2BMEN1KMT2A | |
| SCHEMBL14595454 | 0.76 | IGF1R (0.60) | GRIN1GRIN2BKDM4EGAAMEN1 | |
| SCHEMBL27859939 | 0.75 | GRIN1 (0.45) | GRIN1GRIN2BKDM4EGAAMEN1 | |
| SCHEMBL1226973 | 0.75 | GRIN2B (0.53) | GRIN1GRIN2BKDM4EGAA | |
| SCHEMBL1460466 | 0.75 | GRIN1 (0.45) | GRIN1GRIN2BMEN1KMT2AHSD11B1 | |
| SCHEMBL9429381 | 0.75 | KMT2A (0.45) | GRIN1GRIN2BKDM4EGAAMEN1 | |
| SCHEMBL12625995 | 0.74 | USP2 (0.55) | MEN1KMT2AOPRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| CN-1110685-A | Nitrogen-containing spiro ring | MERCK & CO INC (US) | 1995-10-25 | — | — | CN | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| CN-1053613-A | Nitrogen-containing spiro ring | MERCK & CO INC (US) | 1991-08-07 | — | — | CN | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |