Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 2/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574384 | 1.00 | MAPT (0.47) | MAPTHTTTGM2FOLH1KLK7 | |
| SCHEMBL29931085 | 0.89 | HTT (0.54) | MAPTHTTTGM2FOLH1KLK7 | |
| SCHEMBL6511442 | 0.87 | MAPT (0.52) | MAPTHTTTGM2FOLH1KLK7 | |
| SCHEMBL12076369 | 0.87 | MAPT (0.52) | MAPTHTTTGM2FOLH1KLK7 | |
| SCHEMBL31300270 | 0.80 | MAPT (0.52) | MAPTHTTTGM2KLK7KLK5 | |
| SCHEMBL3898159 | 0.79 | MAPT (0.50) | MAPTHTTTGM2KLK7KLK5 | |
| SCHEMBL13480435 | 0.77 | MAPT (0.65) | MAPTHTTTGM2FOLH1KLK7 | |
| SCHEMBL15679441 | 0.76 | MAPT (0.64) | MAPTHTTTGM2KLK7KLK5 | |
| SCHEMBL13090607 | 0.76 | MAPT (0.64) | MAPTHTTTGM2KLK7KLK5 | |
| SCHEMBL20385193 | 0.76 | MAPT (0.64) | MAPTHTTTGM2KLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906296-A1 | PROCESS FOR THE PREPARATION OF CHIRAL KETO-HETEROCYCLES OF BASIC AMINO ACIDS | WARNER-LAMBERT COMPANY LLC (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997048687-A1 | PROCESS FOR THE PREPARATION OF CHIRAL KETO-HETEROCYCLES OF BASIC AMINO ACIDS | WARNER-LAMBERT COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |