Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460398 | 1.00 | PARP1 (0.48) | PARP1GPR119ATMCA1CA2 | |
| SCHEMBL8391746 | 0.92 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL8391745 | 0.92 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL5224952 | 0.87 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL16846248 | 0.87 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL5224956 | 0.87 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL18129846 | 0.87 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL9052251 | 0.87 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL30872577 | 0.86 | PARP1 (0.49) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL31476848 | 0.86 | PARP1 (0.49) | PARP1GPR119ATMCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736539-A | ANITCARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1998-04-07 | — | — | US | disclosed |
| WO-1995000497-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1995-01-05 | — | — | WO | disclosed |