Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.53 |
| ▸ | SRC | P12931 | 8/20 | 0.53 |
| ▸ | CDK1 | P06493 | 11/20 | 0.50 |
| ▸ | ABL1 | P00519 | 12/20 | 0.49 |
| ▸ | PRKCA | P17252 | 5/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534076 | 0.89 | EGFR (0.55) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL8115017 | 0.88 | EGFR (0.51) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL8115115 | 0.87 | EGFR (0.53) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL4531293 | 0.87 | EGFR (0.57) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL8115586 | 0.85 | GRM4 (0.56) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL8117280 | 0.84 | EGFR (0.74) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL8579664 | 0.83 | SMN1; SMN2 (0.54) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL8115158 | 0.83 | EGFR (0.68) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL8116135 | 0.83 | EGFR (0.69) | EGFRSRCCDK1ABL1PRKCA | |
| SCHEMBL8121174 | 0.82 | EGFR (0.52) | EGFRSRCCDK1ABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998014449-A1 | FUSED PYRAZOLE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | claimed |
| WO-1998014449-A1 | FUSED PYRAZOLE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | disclosed |