Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20721701 | 0.86 | NOTUM (0.53) | NOTUMMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL190291 | 0.84 | NOTUM (0.72) | NOTUMMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL18608896 | 0.84 | MEN1 (0.56) | NOTUMMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3233333 | 0.84 | NOTUM (0.72) | NOTUMMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL28151619 | 0.83 | NOTUM (0.66) | NOTUMMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL23852324 | 0.82 | NOTUM (0.70) | NOTUMMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL4311207 | 0.82 | NOTUM (1.00) | NOTUMMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL189884 | 0.82 | NOTUM (0.70) | NOTUMMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL103310 | 0.82 | NOTUM (0.70) | NOTUMMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8576421 | 0.82 | MEN1 (0.55) | NOTUMMEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015541-A1 | NOVEL ISOXAZOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS | EGIS Gyógyszergyár Rt. (HU) | 1998-04-16 | — | — | WO | disclosed |