Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 12/20 | 0.85 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578669 | 0.92 | EDNRB (1.00) | EDNRBMEN1KMT2A | |
| SCHEMBL8798910 | 0.86 | EDNRB (0.73) | EDNRBTP53MAPTMEN1KMT2A | |
| SCHEMBL8798383 | 0.85 | EDNRB (0.77) | EDNRBTP53MAPTMEN1KMT2A | |
| SCHEMBL8578004 | 0.82 | EDNRB (0.86) | EDNRB | |
| SCHEMBL8578633 | 0.81 | EDNRB (0.73) | EDNRBMAPTKMT2A | |
| SCHEMBL795880 | 0.74 | EDNRB (1.00) | EDNRB | |
| SCHEMBL8578754 | 0.74 | EDNRB (0.83) | EDNRB | |
| SCHEMBL8578916 | 0.73 | EDNRB (0.72) | EDNRBTP53MAPTKMT2A | |
| SCHEMBL6312676 | 0.72 | EDNRB (0.80) | EDNRB | |
| SCHEMBL12044037 | 0.72 | EDNRB (0.55) | EDNRBMAPTMEN1KMT2APLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731321-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-24 | — | — | US | disclosed |