Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.72 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.64 |
| ▸ | JAK3 | P52333 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190264 | 1.00 | EGFR (0.72) | EGFRERBB2ERBB4JAK3AURKB | |
| SCHEMBL4184896 | 0.89 | EGFR (0.78) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL2994028 | 0.84 | EGFR (1.00) | EGFRERBB2ERBB4 | |
| SCHEMBL31605602 | 0.84 | EGFR (1.00) | EGFRERBB2ERBB4 | |
| SCHEMBL7058784 | 0.82 | EGFR (0.80) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL12936070 | 0.81 | EGFR (0.61) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL12936101 | 0.81 | EGFR (0.63) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL2988824 | 0.80 | EGFR (0.67) | EGFRERBB2ERBB4JAK3AURKB | |
| SCHEMBL2988823 | 0.80 | EGFR (0.67) | EGFRERBB2ERBB4JAK3AURKB | |
| SCHEMBL27923377 | 0.80 | EGFR (0.75) | EGFRERBB2ERBB4AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-01-27 | — | — | EP | claimed |
| WO-1997038983-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1997-10-23 | — | — | WO | claimed |