Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836989 | 0.88 | CYP3A4 (0.51) | POLBMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5668131 | 0.86 | POLB (0.47) | POLBMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL19204616 | 0.84 | POLB (0.53) | POLBLMNAHIF1AGALR3ALDH1A1 | |
| SCHEMBL8582885 | 0.82 | CA12 (0.51) | POLBMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL4801866 | 0.82 | POLB (0.45) | POLBL3MBTL1LMNAALDH1A1MAPT | |
| SCHEMBL16800062 | 0.81 | POLB (0.62) | POLBMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL8581155 | 0.80 | POLB (0.43) | POLBMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5665156 | 0.77 | POLB (0.47) | POLBMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5663978 | 0.77 | POLB (0.40) | POLBLMNAHIF1AGALR3ADRB2 | |
| SCHEMBL8582000 | 0.77 | POLB (0.41) | POLBMEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763681-A | ALPHA-2-ADAMANTYLIDENE-ALPHA-METHOXY-META-METHOXYTOLUENE AND RELATED COMPOUNDS AS INTERMEDIATES | TROPIX, INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5225584-A | Phosphonate esters and trialkylsilyl phosphonate esters | TROPIX, INC. (US) | 1993-07-06 | — | — | US | disclosed |