Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16732028 | 0.92 | KCNN4 (0.67) | KCNN4NPSR1SRCHDAC3HDAC4 | |
| SCHEMBL1561399 | 0.88 | KCNN4 (0.62) | KCNN4NPSR1SRCHDAC3HDAC4 | |
| SCHEMBL8784152 | 0.88 | KCNN4 (0.62) | KCNN4NPSR1SRCHDAC3HDAC4 | |
| SCHEMBL28932488 | 0.86 | KCNN4 (0.60) | KCNN4NPSR1SRCHDAC3HDAC4 | |
| SCHEMBL1561571 | 0.85 | KCNN4 (0.58) | KCNN4NPSR1SRCHDAC3HDAC4 | |
| SCHEMBL9383813 | 0.85 | KCNN4 (0.58) | KCNN4NPSR1SRCHDAC3HDAC4 | |
| SCHEMBL728471 | 0.79 | KCNN4 (0.67) | KCNN4NPSR1SRCHDAC3HDAC4 | |
| SCHEMBL4022191 | 0.79 | KCNN4 (0.67) | KCNN4SRCHDAC3HDAC4HDAC1 | |
| SCHEMBL28778735 | 0.78 | KCNN4 (0.42) | KCNN4HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1682976 | 0.78 | KCNN4 (0.64) | KCNN4NPSR1SRCHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840614-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1996041638-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1996-12-27 | — | — | WO | disclosed |