Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13950575 | 1.00 | MAP2K1 (0.39) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL844242 | 1.00 | MAP2K1 (0.39) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL843942 | 1.00 | MAP2K1 (0.39) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL843963 | 0.93 | MAP2K1 (0.41) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL13950768 | 0.93 | MAP2K1 (0.41) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL843962 | 0.93 | MAP2K1 (0.41) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL13765313 | 0.88 | MAP2K1 (0.49) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL10076794 | 0.88 | MAP2K1 (0.49) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL4023862 | 0.86 | MAP2K1 (0.38) | MAP2K1PDE3BPDE3AP2RY12ESR1 | |
| SCHEMBL859794 | 0.84 | MAP2K1 (0.37) | MAP2K1PDE3BPDE3AP2RY12ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188276-B1 | SUBSTITUTED HYDANTOINS | HOFFMANN LA ROCHE (CH) | 2012-03-28 | — | — | EP | disclosed |