Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 19/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.76 |
| ▸ | AKT1 | P31749 | 11/20 | 0.76 |
| ▸ | INCENP | Q9NQS7 | 10/20 | 0.76 |
| ▸ | AURKA | O14965 | 7/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515078 | 1.00 | RPS6KB1 (0.77) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL8514894 | 0.90 | RPS6KB1 (0.84) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL8587924 | 0.90 | RPS6KB1 (0.84) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL17865838 | 0.89 | RPS6KB1 (0.62) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL8510841 | 0.87 | RPS6KB1 (0.85) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL8512137 | 0.87 | RPS6KB1 (1.00) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL18537622 | 0.87 | RPS6KB1 (1.00) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL18537619 | 0.87 | RPS6KB1 (0.79) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL9290650 | 0.87 | RPS6KB1 (0.79) | RPS6KB1AURKBAKT1INCENPAURKA | |
| SCHEMBL9290632 | 0.86 | RPS6KB1 (0.84) | RPS6KB1AURKBAKT1INCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643313-B9 | QUINAZOLINE CARBOXAMIDE AZETIDINES | MERCK PATENT GMBH (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-2643313-A1 | QUINAZOLINE CARBOXAMIDE AZETIDINES | Merck Patent GmbH (DE) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012069146-A1 | QUINAZOLINE CARBOXAMIDE AZETIDINES | MERCK PATENT GMBH (DE) | 2012-05-31 | — | — | WO | disclosed |