Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 3/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | CTSG | P08311 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | BID | P55957 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.45 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.45 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16190919 | 0.92 | TYR (0.86) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL8402774 | 0.92 | TYR (0.85) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL27475908 | 0.87 | TYR (0.77) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL9244588 | 0.87 | TYR (0.77) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL27730242 | 0.87 | TYR (0.77) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL27842379 | 0.85 | TYR (0.74) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL11698312 | 0.85 | TYR (0.74) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL983317 | 0.85 | TYR (0.74) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL1031839 | 0.85 | TYR (0.74) | TYRALOX5TP53CYP3A4MEN1 | |
| SCHEMBL983968 | 0.85 | TYR (0.74) | TYRALOX5TP53CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703780-A4 | USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE | UNIV SYDNEY (AU) | 1998-01-07 | — | — | EP | disclosed |
| CN-1124922-A | Use of natural products and related synthetic compounds for the treatment of cardiovascular diseases | UNIV SYDNEY (AU) | 1996-06-19 | — | — | CN | disclosed |
| EP-0703780-A1 | USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE | THE UNIVERSITY OF SYDNEY (AU) | 1996-04-03 | — | — | EP | disclosed |