Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596135 | 1.00 | KMT2A (0.53) | KMT2AMEN1POLBGAALMNA | |
| SCHEMBL6376088 | 0.87 | SERPINE1 (0.56) | KMT2AMEN1POLBGAAMAPT | |
| SCHEMBL6376092 | 0.87 | SERPINE1 (0.56) | KMT2AMEN1POLBGAAMAPT | |
| SCHEMBL6374742 | 0.86 | LRRK2 (0.55) | KMT2AMEN1POLBGAAIDO1 | |
| SCHEMBL6374734 | 0.86 | LRRK2 (0.55) | KMT2AMEN1POLBGAAIDO1 | |
| SCHEMBL6373090 | 0.85 | SERPINE1 (0.42) | KMT2AMEN1POLBGAALMNA | |
| SCHEMBL6373085 | 0.85 | SERPINE1 (0.42) | KMT2AMEN1POLBGAALMNA | |
| SCHEMBL6371821 | 0.84 | SMN1; SMN2 (0.46) | KMT2AMEN1POLBMAPTNPC1 | |
| SCHEMBL6371814 | 0.84 | SMN1; SMN2 (0.46) | KMT2AMEN1POLBMAPTNPC1 | |
| SCHEMBL6373302 | 0.83 | KMT2A (0.45) | KMT2AMEN1POLBGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655060-B1 | PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES | XENOVA LTD (GB) | 1998-01-14 | — | — | EP | claimed |
| EP-0655060-B1 | PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES | XENOVA LTD (GB) | 1998-01-14 | — | — | EP | disclosed |
| US-5700804-A | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITORS | XENOVA LIMITED (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0655060-A1 | PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES | XENOVA LIMITED (GB) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004512-A1 | PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES | XENOVA LIMITED (GB) | 1994-03-03 | — | — | WO | disclosed |