Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.42 |
| ▸ | AXL | P30530 | 4/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 9/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | LTK | P29376 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6126061 | 0.93 | TYRO3 (0.51) | JAK2AXLTYRO3FGFR1KDR | |
| SCHEMBL9947530 | 0.88 | TYRO3 (0.48) | JAK2AXLTYRO3FGFR1KDR | |
| SCHEMBL8583196 | 0.88 | JAK2 (0.44) | JAK2AXLTYRO3FGFR1KDR | |
| SCHEMBL8583522 | 0.88 | JAK2 (0.44) | JAK2AXLTYRO3FGFR1KDR | |
| SCHEMBL8583535 | 0.87 | JAK2 (0.51) | JAK2AXLTYRO3FGFR1MERTK | |
| SCHEMBL8583199 | 0.87 | JAK2 (0.51) | JAK2AXLTYRO3FGFR1MERTK | |
| SCHEMBL8596547 | 0.86 | TYRO3 (0.47) | JAK2AXLTYRO3FGFR1KDR | |
| SCHEMBL8583537 | 0.86 | JAK2 (0.51) | JAK2AXLTYRO3FGFR1MERTK | |
| SCHEMBL8597086 | 0.86 | TYRO3 (0.46) | JAK2AXLTYRO3FGFR1KDR | |
| SCHEMBL8586853 | 0.86 | JAK2 (0.43) | JAK2AXLTYRO3FGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068440-A1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |