Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.57 |
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604568 | 0.85 | SLC22A12 (0.60) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL1553033 | 0.84 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8603044 | 0.81 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL1553972 | 0.80 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8602176 | 0.79 | SLC22A12 (0.61) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8602713 | 0.78 | SLC22A12 (0.63) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL1554927 | 0.78 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL16587422 | 0.76 | SLC22A12 (0.70) | SLC22A12KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1554767 | 0.73 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL17316681 | 0.73 | SLC22A12 (0.61) | SLC22A12KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |