Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 8/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873297 | 1.00 | METAP1 (0.46) | METAP1HTR2AHTR2CHTR2BACHE | |
| SCHEMBL8596599 | 0.86 | METAP1 (0.41) | METAP1HTR2AHTR2CHTR2BACHE | |
| SCHEMBL8596603 | 0.86 | METAP1 (0.41) | METAP1HTR2AHTR2CHTR2BACHE | |
| SCHEMBL8874368 | 0.86 | METAP1 (0.41) | METAP1HTR2AHTR2CHTR2BACHE | |
| SCHEMBL8598137 | 0.82 | METAP1 (0.67) | METAP1HTR2AHTR2CHTR2BACHE | |
| SCHEMBL8875167 | 0.82 | METAP1 (0.67) | METAP1HTR2AHTR2CHTR2BACHE | |
| SCHEMBL8874791 | 0.79 | METAP1 (0.52) | METAP1ACHEMAPTL3MBTL1CYP19A1 | |
| SCHEMBL8600859 | 0.79 | METAP1 (0.52) | METAP1ACHEMAPTL3MBTL1CYP19A1 | |
| SCHEMBL8598468 | 0.79 | METAP1 (0.50) | METAP1HTR2AHTR2CHTR2BACHE | |
| SCHEMBL8873164 | 0.79 | METAP1 (0.50) | METAP1HTR2AHTR2CHTR2BACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | disclosed |
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |