Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 5/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873170 | 1.00 | METAP1 (0.62) | METAP1ACHECYP19A1KDM4EALDH1A1 | |
| SCHEMBL8601454 | 1.00 | METAP1 (0.62) | METAP1ACHECYP19A1KDM4EALDH1A1 | |
| SCHEMBL8599621 | 0.89 | METAP1 (0.64) | METAP1ACHECYP19A1 | |
| SCHEMBL8599618 | 0.89 | METAP1 (0.64) | METAP1ACHECYP19A1 | |
| SCHEMBL8874197 | 0.89 | METAP1 (0.64) | METAP1ACHECYP19A1 | |
| SCHEMBL8597968 | 0.87 | METAP1 (0.47) | METAP1ACHEGAAL3MBTL1 | |
| SCHEMBL8597966 | 0.87 | METAP1 (0.47) | METAP1ACHEGAAL3MBTL1 | |
| SCHEMBL8872793 | 0.87 | METAP1 (0.47) | METAP1ACHEGAAL3MBTL1 | |
| SCHEMBL8598724 | 0.86 | METAP1 (0.69) | METAP1ACHECYP19A1HTR2AHTR2C | |
| SCHEMBL8874562 | 0.86 | METAP1 (0.69) | METAP1ACHECYP19A1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | disclosed |
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |