Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | XIAP | P98170 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258044 | 0.87 | MEN1 (0.44) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL6095875 | 0.84 | XIAP (0.41) | MEN1KMT2AMAPTXIAPRAB9A | |
| SCHEMBL6093878 | 0.77 | PTPRC (0.54) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL6110147 | 0.77 | CCR6 (0.51) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL6257893 | 0.75 | MEN1 (0.39) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL6094612 | 0.74 | KDM4E (0.40) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL6096689 | 0.74 | HPGD (0.40) | MEN1KMT2AMAPTXIAPRAB9A | |
| SCHEMBL6094828 | 0.73 | NPC1 (0.38) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL6256453 | 0.73 | MAPT (0.48) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL7749783 | 0.73 | MEN1 (0.42) | MEN1KMT2AMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780496-A | Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions | SUGEN, INC. (US) | 1998-07-14 | — | — | US | claimed |