Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.50 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860179 | 1.00 | HRH4 (0.50) | HRH4ACACBHRH3 | |
| SCHEMBL846850 | 0.85 | HRH4 (0.68) | HRH4ACACBHRH3 | |
| SCHEMBL19458953 | 0.85 | HRH4 (0.68) | HRH4ACACBHRH3 | |
| SCHEMBL847300 | 0.85 | HRH4 (0.68) | HRH4ACACBHRH3 | |
| SCHEMBL1588762 | 0.84 | HRH4 (0.69) | HRH4HRH3 | |
| SCHEMBL1587979 | 0.84 | HRH4 (0.69) | HRH4HRH3 | |
| SCHEMBL19458966 | 0.84 | HRH4 (0.69) | HRH4HRH3 | |
| SCHEMBL860337 | 0.83 | HRH4 (0.59) | HRH4 | |
| SCHEMBL860338 | 0.83 | HRH4 (0.59) | HRH4 | |
| SCHEMBL860178 | 0.82 | HRH4 (0.47) | HRH4ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524363-A | — | — | 2011-09-01 | — | — | JP | claimed |
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | claimed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | claimed |