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SCHEMBL860272

SCHEMBL860272

O=C1NC(=S)S/C1=C/c1cnn2ccc(Nc3cccc(Cl)c3)nc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTP4A3 O75365 2/20 0.45
▸ CRHBP P24387 2/20 0.45
▸ CRHR2 Q13324 2/20 0.45
▸ PIM1 P11309 4/20 0.44
▸ MTOR P42345 5/20 0.42
▸ RPTOR Q8N122 3/20 0.42
▸ MLST8 Q9BVC4 3/20 0.42
▸ DNM1 Q05193 1/20 0.42
▸ NAT1 P18440 2/20 0.41
▸ MYC P01106 1/20 0.41
▸ MAX P61244 1/20 0.41
▸ ADAMTS5 Q9UNA0 2/20 0.40
▸ MGAM O43451 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ SI P14410 1/20 0.40
▸ MGAM2 Q2M2H8 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ PLA2G1B P04054 1/20 0.39
▸ ATG4B Q9Y4P1 1/20 0.39
▸ PIK3CD O00329 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13073902 1.00 PTP4A3 (0.45) PTP4A3CRHBPCRHR2PIM1MTOR
SCHEMBL860273 1.00 PTP4A3 (0.45) PTP4A3CRHBPCRHR2PIM1MTOR
SCHEMBL861503 0.91 PIM1 (0.49) PIM1ADAMTS5MGAMGAASI
SCHEMBL861502 0.91 PIM1 (0.49) PIM1ADAMTS5MGAMGAASI
SCHEMBL12978877 0.91 PIM1 (0.49) PIM1ADAMTS5MGAMGAASI
SCHEMBL14679084 0.84 PIM1 (0.39) PIM1CSNK2B
SCHEMBL861027 0.81 CSNK2B (0.46) PIM1HPGDCSNK2B
SCHEMBL861026 0.81 CSNK2B (0.46) PIM1HPGDCSNK2B
SCHEMBL12978737 0.81 CSNK2B (0.46) PIM1HPGDCSNK2B
SCHEMBL1487820 0.81 CSNK2B (0.44) PIM1CSNK2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8367681-B2 Pyrazolopyrimidines and related heterocycles as kinase inhibitors CYLENE PHARMACEUTICALS, INC. (US) 2013-02-05 — — US disclosed
US-8367681-B2 Pyrazolopyrimidines and related heterocycles as kinase inhibitors CYLENE PHARMACEUTICALS, INC. (US) 2013-02-05 — — US disclosed
US-8367681-B2 Pyrazolopyrimidines and related heterocycles as kinase inhibitors CYLENE PHARMACEUTICALS, INC. (US) 2013-02-05 — — US disclosed
EP-2432473-A1 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS Cylene Pharmaceuticals, Inc. (US) 2012-03-28 — — EP disclosed
US-20100331314-A1 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS SENHWA BIOSCIENCES, INC. (TW) 2010-12-30 — — US disclosed
US-20100331314-A1 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS SENHWA BIOSCIENCES, INC. (TW) 2010-12-30 — — US disclosed
US-20100331314-A1 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS SENHWA BIOSCIENCES, INC. (TW) 2010-12-30 — — US disclosed
WO-2010135581-A1 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS CYLENE PHARMACEUTICALS, INC. (US) 2010-11-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100331314-A1 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS PIM1, PIM2, PIM3 PTP4A3 878/4885CRHBP 3196/4885CRHR2 3644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.