Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860448 | 0.87 | JAK2 (0.32) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859942 | 0.86 | JAK2 (0.34) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859292 | 0.84 | JAK2 (0.34) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859941 | 0.82 | — | — | |
| SCHEMBL859689 | 0.79 | AXL (0.53) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859459 | 0.78 | JAK2 (0.33) | JAK2JAK1FGFR1 | |
| SCHEMBL859460 | 0.78 | SRC (0.35) | — | |
| SCHEMBL3757543 | 0.77 | JAK1 (0.45) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL3755715 | 0.77 | AXL (0.45) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL3758174 | 0.76 | AXL (0.46) | AXLTYRO3MERTKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |