Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.59 |
| ▸ | JAK1 | P23458 | 5/20 | 0.58 |
| ▸ | JAK3 | P52333 | 4/20 | 0.58 |
| ▸ | TYK2 | P29597 | 3/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101593 | 0.90 | JAK2 (0.62) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Phosphoric Acid SCHEMBL28297504 | 0.88 | JAK2 (0.61) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL99804 | 0.85 | AURKA (0.51) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL4092640 | 0.84 | JAK2 (0.61) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL103490 | 0.84 | JAK2 (0.52) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL4092636 | 0.81 | JAK1 (0.64) | JAK2JAK1JAK3TYK2CIT | |
| Trifluoroacetic Acid SCHEMBL99863 | 0.81 | JAK2 (0.49) | JAK2HDAC6JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL101615 | 0.80 | JAK2 (0.61) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL100405 | 0.80 | JAK2 (0.61) | JAK2HDAC6HDAC1JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL30663370 | 0.80 | JAK2 (0.61) | JAK2HDAC6HDAC1JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |