Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | PGK2 | P07205 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2505187 | 0.84 | PTGS1 (0.51) | PTGS1PTGS2DHODHCYP1A2CYP3A4 | |
| SCHEMBL11071233 | 0.79 | ACP3 (0.41) | ACP3MAPTPGK1PGK2NPC1 | |
| SCHEMBL118694 | 0.79 | PTGS1 (0.47) | PTGS1PTGS2DHODHCYP1A2CYP3A4 | |
| SCHEMBL3305733 | 0.75 | PTGS1 (0.56) | PTGS1PTGS2DHODHCYP1A2CYP3A4 | |
| SCHEMBL30556624 | 0.74 | PTGS1 (0.54) | PTGS1PTGS2DHODHCYP1A2CYP3A4 | |
| SCHEMBL31211453 | 0.74 | PTGS1 (0.54) | PTGS1PTGS2DHODHCYP1A2CYP3A4 | |
| SCHEMBL8373781 | 0.74 | PTGS1 (0.54) | PTGS1PTGS2DHODHCYP1A2CYP3A4 | |
| SCHEMBL1758978 | 0.74 | RXFP1 (0.56) | PTGS1PTGS2MAPTRXFP1NPC1 | |
| SCHEMBL19660422 | 0.74 | PTGS1 (0.54) | PTGS1PTGS2DHODHCYP1A2CYP3A4 | |
| SCHEMBL2832275 | 0.74 | PTGS1 (0.50) | PTGS1PTGS2DHODHCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633237-A | Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treatment of neurotoxic injury | G.D. SEARLE & CO. (US) | 1997-05-27 | — | — | US | claimed |
| US-5360796-A | Treatment of hypoxia, anoxia or ischemia | G. D. SEARLE & CO. (US) | 1994-11-01 | — | — | US | claimed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | claimed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | claimed |
| US-5716964-A | BRAIN DISORDERS; ANTIISCHEMIC AGENTS | G.D. SEARLE & CO. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5633237-A | Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treatment of neurotoxic injury | G.D. SEARLE & CO. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5360796-A | Treatment of hypoxia, anoxia or ischemia | G. D. SEARLE & CO. (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |