Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 8/20 | 0.37 |
| ▸ | JAK1 | P23458 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | PAK4 | O96013 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | LTK | P29376 | 2/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859410 | 0.95 | AXL (0.45) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL860398 | 0.89 | AXL (0.44) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL100828 | 0.85 | JAK2 (0.47) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL13058339 | 0.85 | JAK2 (0.47) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859773 | 0.85 | JAK2 (0.47) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL3751971 | 0.83 | AXL (0.47) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL860504 | 0.82 | AXL (0.48) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859489 | 0.82 | JAK2 (0.42) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL3762319 | 0.81 | AXL (0.56) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL13074729 | 0.81 | AXL (0.56) | AXLTYRO3MERTKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |