Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.62 |
| ▸ | CCKBR | P32239 | 10/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.50 |
| ▸ | CCKAR | P32238 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092485 | 0.94 | KCNH2 (0.57) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL8611972 | 0.86 | KCNH2 (0.77) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL8611973 | 0.86 | KCNH2 (0.77) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL8611266 | 0.83 | KCNH2 (0.66) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL4697333 | 0.83 | KCNH2 (0.66) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL8611080 | 0.80 | KCNH2 (0.62) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL4702944 | 0.80 | KCNH2 (0.63) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL4697535 | 0.79 | KCNH2 (0.59) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL6994842 | 0.79 | KCNH2 (0.62) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL4699922 | 0.78 | KCNH2 (0.59) | KCNH2CCKBRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817658-A | ADMINISTERING A DIAZEPINE COMPOUND; DISEASES OF THE EAR | MERCK & COMPANY, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5776930-A | CARDIOVASCULAR DISORDERS | MERCK & COMPANY, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5595990-A | TREATMENT OF CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5426185-A | Antiarrhythmia agents having reduced side effects | MERCK & CO., INC. (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995014471-A1 | ANTIARRHYTHMIC BENZODIAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |