Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.62 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.62 |
| ▸ | JAK2 | O60674 | 13/20 | 0.59 |
| ▸ | JAK1 | P23458 | 11/20 | 0.59 |
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | PAK4 | O96013 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | LTK | P29376 | 2/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.56 |
| ▸ | CLK2 | P49760 | 2/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.56 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3753686 | 0.99 | AXL (0.63) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL3758280 | 0.94 | AXL (0.63) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL860000 | 0.94 | AXL (0.63) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL3757305 | 0.91 | AXL (0.60) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL859248 | 0.91 | AXL (0.60) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL3763861 | 0.91 | AXL (0.68) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL3749183 | 0.90 | AXL (0.62) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL859042 | 0.89 | AXL (0.61) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL27868343 | 0.89 | AXL (0.61) | AXLTYRO3JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL859843 | 0.89 | AXL (0.68) | AXLTYRO3JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |