Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8610422 | 1.00 | EDNRA (0.32) | EDNRALMNAMAPK1HTT | |
| SCHEMBL2241925 | 0.67 | — | — | |
| SCHEMBL4364436 | 0.64 | MAOB (0.48) | LMNAMAPK1HTT | |
| SCHEMBL27149 | 0.64 | MAOB (0.48) | LMNAMAPK1HTT | |
| SCHEMBL8534568 | 0.63 | — | — | |
| SCHEMBL8534570 | 0.63 | — | — | |
| SCHEMBL17138213 | 0.63 | KMT2A (0.47) | LMNAMAPK1HTT | |
| SCHEMBL17138211 | 0.63 | KMT2A (0.47) | LMNAMAPK1HTT | |
| SCHEMBL27987849 | 0.63 | MAOB (0.47) | LMNAMAPK1HTT | |
| SCHEMBL28066691 | 0.63 | STAT3 (0.43) | LMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770382-A | RETINOIC ACID AND RETINOID X RECEPTOR AGONISTS; TREATINGSKIN, EYE, BRAIN, AND CARDIOVASCULAR DISORDERS; CANCER | LIGAND PHARMACEUTICALS, INC. (US) | 1998-06-23 | — | — | US | disclosed |
| US-5770378-A | A VITAMINE A METABOLITE, POTENT DRUGS TREATING SKIN DISEASES, CANCER, EYE DISEASES, CARDIOVASCULAR DISORDERS | LIGAND PHARMACEUTICALS, INC. (US) | 1998-06-23 | — | — | US | disclosed |
| US-5770383-A | ACTIVATE RETINOID RECEPTORS | LIGAND PHARMACEUTICALS, INC. (US) | 1998-06-23 | — | — | US | disclosed |