Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 10/20 | 0.49 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9226176 | 1.00 | CYP3A4 (0.51) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL9225036 | 0.87 | CYP3A4 (0.56) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL8612503 | 0.87 | CYP3A4 (0.56) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL9224011 | 0.87 | CYP3A4 (0.56) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL9228195 | 0.87 | CYP3A4 (0.56) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL8612068 | 0.85 | ABCB1 (0.57) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL9229431 | 0.85 | ABCB1 (0.57) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL9221568 | 0.85 | ABCB1 (0.58) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL27396845 | 0.85 | ABCB1 (0.58) | CYP3A4ALOX15KDM4EABCB1KCNE1 | |
| SCHEMBL9221561 | 0.85 | ABCB1 (0.58) | CYP3A4ALOX15KDM4EABCB1KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837702-A | HAVING POTASSIUM CHANNEL ACTIVATING ACTIVITY USEFUL AS CARDIOVASCULAR AGENTS AND TREATMENT OF ISCHEMIA | BRISTOL-MYERS SQUIBB CO. (US) | 1998-11-17 | — | — | US | claimed |
| EP-0648758-A1 | 4-Arylamino-benzopyran and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-04-19 | — | — | EP | claimed |
| US-5837702-A | HAVING POTASSIUM CHANNEL ACTIVATING ACTIVITY USEFUL AS CARDIOVASCULAR AGENTS AND TREATMENT OF ISCHEMIA | BRISTOL-MYERS SQUIBB CO. (US) | 1998-11-17 | — | — | US | disclosed |
| EP-0648758-A1 | 4-Arylamino-benzopyran and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-04-19 | — | — | EP | disclosed |