Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 14/20 | 1.00 |
| ▸ | SRD5A1 | P18405 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | HSD3B1 | P14060 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613203 | 1.00 | SRD5A2 (1.00) | SRD5A2SRD5A1LMNACYP3A4CYP2C9 | |
| SCHEMBL8615926 | 0.84 | SRD5A1 (1.00) | SRD5A2SRD5A1HSD3B1 | |
| SCHEMBL8615928 | 0.84 | SRD5A1 (1.00) | SRD5A2SRD5A1HSD3B1 | |
| SCHEMBL9540631 | 0.84 | SRD5A2 (0.72) | SRD5A2SRD5A1 | |
| SCHEMBL29842895 | 0.80 | SRD5A2 (0.67) | SRD5A2SRD5A1LMNACYP3A4CYP2C9 | |
| SCHEMBL8532138 | 0.80 | SRD5A2 (1.00) | SRD5A2 | |
| SCHEMBL8611390 | 0.80 | SRD5A2 (1.00) | SRD5A2SRD5A1 | |
| SCHEMBL8611644 | 0.80 | SRD5A2 (1.00) | SRD5A2 | |
| SCHEMBL8611392 | 0.80 | SRD5A2 (1.00) | SRD5A2SRD5A1 | |
| SCHEMBL8613221 | 0.80 | SRD5A2 (1.00) | SRD5A2SRD5A1LMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641356-B1 | INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE | GLAXO WELLCOME INC (US) | 1998-04-22 | — | — | EP | claimed |
| EP-0641356-B1 | INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE | GLAXO WELLCOME INC (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5543406-A | TREATING ANDROGEN RESPONSIVE OR MEDIATED DISEASE | GLAXO WELLCOME, INC. (US) | 1996-08-06 | — | — | US | disclosed |
| WO-1993013124-A1 | INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE | GLAXO INC. (US) | 1993-07-08 | — | — | WO | disclosed |