Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621033 | 0.87 | CYP2A6 (0.60) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL28550147 | 0.84 | MEN1 (0.55) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL4603999 | 0.81 | CYP2A6 (0.50) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL11371853 | 0.79 | HTR2A (0.57) | CYP2A6IMPDH2HTTMEN1KMT2A | |
| SCHEMBL4604316 | 0.79 | CYP2A6 (0.47) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL27719415 | 0.78 | CYP2A6 (0.58) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL7541339 | 0.77 | CYP2A6 (0.53) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL3697106 | 0.77 | KMT2A (0.51) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL3697104 | 0.77 | KMT2A (0.51) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL27511500 | 0.77 | CYP2A6 (0.49) | CYP2A6IMPDH2HPGDHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106117113-A | Polysubstituted carbazole, derivant and synthetic method thereof | 湘潭大学 | 2016-11-16 | — | — | CN | claimed |
| CN-106117113-B | Polysubstituted carbazole, derivative and its synthetic method | 湘潭大学 | 2019-08-16 | — | — | CN | disclosed |
| CN-106117113-A | Polysubstituted carbazole, derivant and synthetic method thereof | 湘潭大学 | 2016-11-16 | — | — | CN | disclosed |
| CN-101486709-A | Method for synthesizing 3-(tetrahydropyran-2'-yl) indole | UNIV ZHEJIANG (CN) | 2009-07-22 | — | — | CN | disclosed |
| CN-1680320-A | Beta, beta-double indolene compound, synthesis and use thereof | SHANGHAI ORGANIC CHEMICAL INST (CN) | 2005-10-12 | — | — | CN | disclosed |
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |
| US-4059583-A | CARDIAC RATE LOWERING | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-11-22 | — | — | US | disclosed |