Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142605 | 1.00 | NPC1 (0.45) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL1258616 | 0.98 | NPC1 (0.47) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL3752915 | 0.96 | NPC1 (0.43) | NPC1NAAA | |
| SCHEMBL28333594 | 0.93 | NPC1 (0.38) | NPC1NAAA | |
| SCHEMBL3345124 | 0.91 | NPC1 (0.48) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL1260397 | 0.91 | NPC1 (0.48) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL3747088 | 0.89 | NPC1 (0.45) | NPC1NAAACA1CA2 | |
| SCHEMBL9011682 | 0.89 | NPC1 (0.54) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL9011791 | 0.89 | NPC1 (0.54) | NPC1NAAACA1CA2HPGD | |
| SCHEMBL9011906 | 0.89 | NPC1 (0.54) | NPC1NAAACA1CA2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |
| US-5446088-A | A stable acidity mixture in solvent comprising a copolymer of polysilicate and polysilsesquioxane; forming a protective coatings | DOW CORNING CORPORATION (US) | 1995-08-29 | — | — | US | disclosed |