Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.44 |
| ▸ | ACP1 | P24666 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8615054 | 0.90 | PDE10A (0.55) | PDE10AACP1MEN1KMT2AATM | |
| SCHEMBL8614063 | 0.88 | PDE10A (0.46) | PDE10AACP1MEN1KMT2AATM | |
| SCHEMBL8615130 | 0.88 | ACP1 (0.45) | PDE10AACP1MEN1KMT2AATM | |
| SCHEMBL8614048 | 0.87 | ACP1 (0.42) | PDE10AACP1MEN1KMT2AATM | |
| SCHEMBL8620930 | 0.87 | PDE10A (0.44) | PDE10AACP1MEN1KMT2AATM | |
| SCHEMBL8613965 | 0.87 | PDE10A (0.46) | PDE10AACP1MEN1KMT2AATM | |
| SCHEMBL8617748 | 0.87 | ACP1 (0.52) | ACP1MEN1KMT2ATACR3SMN1; SMN2 | |
| SCHEMBL8614159 | 0.87 | PDE10A (0.45) | PDE10AACP1MEN1KMT2AATM | |
| SCHEMBL8619516 | 0.86 | PDE10A (0.44) | PDE10AACP1MEN1KMT2AATM | |
| SCHEMBL8620369 | 0.84 | MEN1 (0.43) | PDE10AACP1MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |