Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | GGT1 | P19440 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL163170 | 1.00 | TSHR (0.46) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL8616423 | 1.00 | TSHR (0.46) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL27590654 | 0.97 | TSHR (0.44) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL9177238 | 0.95 | TSHR (0.42) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL9179079 | 0.89 | TSHR (0.50) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL1685057 | 0.89 | TSHR (0.50) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL29247968 | 0.89 | TSHR (0.38) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL9180120 | 0.86 | TSHR (0.48) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL277350 | 0.85 | TSHR (0.42) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL3372717 | 0.84 | TSHR (0.46) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827855-A | ANTICHOLESTEROL AGENTS TREATING CARDIOVASCULAR DISORDERS; ENZYME INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1998-10-27 | — | — | US | disclosed |
| CN-1039642-C | Derivative of hexahydronaphthalene ester, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-09-02 | — | — | CN | disclosed |
| EP-0605230-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5451688-A | Inhibit biosynthesis of cholesterol | SANKYO COMPANY, LIMITED (JP) | 1995-09-19 | — | — | US | disclosed |
| CN-1094707-A | Hexahydro-naphthalene ester derivative, their preparation and their application aspect treatment | SANKYO CO (JP) | 1994-11-09 | — | — | CN | disclosed |
| EP-0605230-A1 | Hexanhydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-07-06 | — | — | EP | disclosed |