Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | G6PD | P11413 | 1/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619384 | 0.93 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8616025 | 0.86 | DHODH (0.62) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8619026 | 0.86 | DHODH (0.62) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL9017547 | 0.85 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8616015 | 0.85 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8615204 | 0.85 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL9160491 | 0.85 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8615207 | 0.84 | DHODH (0.60) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8620911 | 0.82 | DHODH (0.64) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL9129374 | 0.82 | DHODH (0.64) | DHODHKMT2AMEN1G6PDCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632017-B1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-06 | — | — | EP | disclosed |
| EP-0632017-A1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-01-04 | — | — | EP | disclosed |