Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 7/20 | 0.42 |
| ▸ | HINT1 | P49773 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616208 | 1.00 | NT5E (0.49) | NT5ECYP1A2SLC29A1HINT1ADORA2A | |
| SCHEMBL8621820 | 0.86 | SLC29A1 (0.46) | NT5ECYP1A2SLC29A1STING1 | |
| SCHEMBL8621824 | 0.86 | SLC29A1 (0.46) | NT5ECYP1A2SLC29A1STING1 | |
| SCHEMBL8624686 | 0.86 | NT5E (0.45) | NT5ECYP1A2SLC29A1HINT1ADORA3 | |
| SCHEMBL8624690 | 0.86 | NT5E (0.45) | NT5ECYP1A2SLC29A1HINT1ADORA3 | |
| SCHEMBL8376939 | 0.86 | CYP1A2 (0.43) | NT5ECYP1A2SLC29A1HINT1ADORA2A | |
| SCHEMBL8619465 | 0.83 | SLC29A1 (0.44) | NT5ESLC29A1ADORA2AADORA3ADORA1 | |
| SCHEMBL8619475 | 0.83 | SLC29A1 (0.44) | NT5ESLC29A1ADORA2AADORA3ADORA1 | |
| SCHEMBL8621051 | 0.82 | NT5E (0.47) | NT5ESLC29A1ADORA2AADORA3ADORA1 | |
| SCHEMBL8621057 | 0.82 | NT5E (0.47) | NT5ESLC29A1ADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817799-A | 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0540686-B1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | US COMMERCE (US) | 1995-08-30 | — | — | EP | disclosed |
| US-5336764-A | 2'-fluorofuranosyl derivatives and novel method of preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-08-09 | — | — | US | disclosed |
| WO-1992001700-A1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) | 1992-02-06 | — | — | WO | disclosed |