Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.89 |
| ▸ | ESR1 known ✓ | P03372 | 5/20 | 0.65 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.65 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 2/20 | 0.65 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.65 |
| ▸ | IDH1 known ✓ | O75874 | 1/20 | 0.65 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.65 |
| ▸ | ESR2 known ✓ | Q92731 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.89 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.89 |
| ▸ | MAPT | P10636 | 3/20 | 0.89 |
| ▸ | LMNA | P02545 | 3/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.89 |
| ▸ | TP53 | P04637 | 2/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.89 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.89 |
| ▸ | EBP | Q15125 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL8614802 | 1.00 | KMT2A (0.89) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL8614814 | 1.00 | KMT2A (0.89) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL8613135 | 0.99 | KMT2A (0.87) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL8614947 | 0.99 | KMT2A (0.87) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL27467552 | 0.99 | KMT2A (0.87) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL8614087 | 0.99 | KMT2A (0.87) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL8612826 | 0.99 | KMT2A (0.87) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL8612350 | 0.99 | KMT2A (0.87) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL27467106 | 0.99 | KMT2A (0.87) | KMT2AKDM4EMEN1CYP2D6MAPT | |
| Citric Acid SCHEMBL27554120 | 0.99 | KMT2A (0.87) | KMT2AKDM4EMEN1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720597-B1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMA INC (US) | 1998-04-29 | — | — | EP | disclosed |
| CN-1167437-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL INC (US) | 1997-12-10 | — | — | CN | disclosed |
| EP-0794771-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0720597-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1996016646-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1995008528-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-30 | — | — | WO | disclosed |