⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245951 | 0.76 | — | — | |
| SCHEMBL16245774 | 0.76 | — | — | |
| SCHEMBL16237641 | 0.73 | — | — | |
| SCHEMBL2180649 | 0.60 | — | — | |
| SCHEMBL671575 | 0.60 | — | — | |
| SCHEMBL2041077 | 0.60 | — | — | |
| SCHEMBL14013717 | 0.56 | — | — | |
| SCHEMBL1483363 | 0.56 | — | — | |
| SCHEMBL884123 | 0.55 | MEN1 (0.32) | — | |
| SCHEMBL2093584 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 201 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107459521-B | Novel inhibitors of FLT3 kinase and uses thereof | 合肥中科普瑞昇生物医药科技有限公司 | 2021-04-16 | — | — | CN | claimed |
| US-10975082-B2 | Inhibitor of FLT3 kinase and use thereof | PRECEDO PHARMACEUTICALS CO., LTD (CN) | 2021-04-13 | — | — | US | claimed |
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | claimed |
| US-10738028-B2 | Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor | RUDONG RUIEN PHARMACEUTICAL TECHNOLOGY CO. LTD (CN) | 2020-08-11 | — | — | US | claimed |
| CN-107362162-B | Antitumor application of spirotricyclic and spiropentacyclic peptide deformylase inhibitor | 如东瑞恩医药科技有限公司 | 2019-12-13 | — | — | CN | claimed |
| CN-107365302-B | Spiro three-membered ring, spirofive-membered ring peptoid deformylase inhibitors | 如东瑞恩医药科技有限公司 | 2019-12-13 | — | — | CN | claimed |
| CN-107365303-B | Antibacterial application of spirotricyclic and spiropentacyclic peptide deformylase inhibitor | 如东瑞恩医药科技有限公司 | 2019-12-13 | — | — | CN | claimed |
| US-20190194165-A1 | SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOR | RUDONG RUIEN PHARMACEUTICAL TECHNOLOGY CO. LTD (CN) | 2019-06-27 | — | — | US | claimed |
| EP-3483155-A1 | SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOUR. | Rudong Ruien Pharmaceutical Technology Co., Ltd. (CN) | 2019-05-15 | — | — | EP | claimed |
| EP-3466952-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | Precedo Pharmaceuticals Co., Ltd. (CN) | 2019-04-10 | — | — | EP | claimed |
| US-7115617-B2 | Amino-substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2006-10-03 | — | — | US | claimed |
| US-20050245547-A1 | 6-((6,7-Bis(methoxy)-4-quinolinyl)oxy)-N-(3-methylphenyl)-1-benzofuran-3-carboxamide;antiproliferative; -metastasis; -carcinogenic; -tumor; -inflammatory; -arthritic agents;hypotensive agents; myocardium necrosis; rheumatic diseases; tyrosine kinase inhibitors; antiallergens; asthma | AMGEN INC. | 2005-11-03 | — | — | US | claimed |
| WO-2005073224-A2 | QUINOLINE QUINAZOLINE PYRIDINE AND PYRIMIDINE COUNDS AND THEIR USE IN THE TREATMENT OF INFLAMMATION ANGIOGENESIS AND CANCER | AMGEN INC (US) | 2005-08-11 | — | — | WO | claimed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | claimed |
| EP-1418916-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-05-19 | — | — | EP | claimed |
| US-20030125346-A1 | Amino-substituted pyrimidinyl derivatives and methods of use | AMGEN INC. | 2003-07-03 | — | — | US | claimed |
| WO-2003018022-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-03-06 | — | — | WO | claimed |
| EP-1134214-A1 | PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2001-09-19 | — | — | EP | claimed |
| EP-0662477-A1 | Heterobicyclic compounds with fungicidal activity | ISAGRO S.p.A. (IT) | 1995-07-12 | — | — | EP | claimed |
| US-4183856-A | FROM HETEROAROMATIC SECONDARY AMINES AND CARBAMOYL HALOGENIDES IN THE PRESENCE OF A LEWIS ACID | SHIONOGI & CO., LTD. (JP) | 1980-01-15 | — | — | US | claimed |