Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.56 |
| ▸ | GRM5 | P41594 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23843579 | 0.84 | CHRM2 (0.57) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL30707880 | 0.82 | GRM5 (0.66) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL6132140 | 0.82 | GRM5 (0.66) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL2155272 | 0.82 | CHRM2 (0.56) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL19291472 | 0.82 | CHRM2 (0.56) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL29745229 | 0.82 | CHRM2 (0.56) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL5886631 | 0.81 | CHRM2 (0.52) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL7601866 | 0.81 | GRM5 (0.56) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL29994376 | 0.81 | GRM5 (0.56) | CHRM2CHRM1CHRM3GRM5CA12 | |
| SCHEMBL16298669 | 0.81 | CHRM2 (0.55) | CHRM2CHRM1CHRM3GRM5CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733914-A | Pyrido 2, 3-d!pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation | WARNER-LAMBERT COMPANY (US) | 1998-03-31 | — | — | US | disclosed |
| US-5620981-A | ANTICARCINOGENIC AGENTS, ATHEROSCLEROSIS, RESTENOSIS, PSORIASIS | WARNER-LAMBERT COMPANY (US) | 1997-04-15 | — | — | US | disclosed |