SCHEMBL8618461

SCHEMBL8618461

Fc1cc(Br)ccc1-c1ccc(-c2ccc(OCc3ccccc3)cc2F)c(F)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.52
GSTP1 P09211 1/20 0.47
S1PR1 P21453 1/20 0.46
S1PR3 Q99500 1/20 0.46
PARP15 Q460N3 1/20 0.45
PARP10 Q53GL7 1/20 0.45
MAOA P21397 2/20 0.45
TOP1 P11387 1/20 0.45
MCL1 Q07820 1/20 0.45
ALOX5 P09917 1/20 0.44
ALOX5AP P20292 1/20 0.43
FEN1 P39748 1/20 0.43
FFAR1 O14842 1/20 0.43
PPARD Q03181 1/20 0.43
PTGES O14684 1/20 0.43
CTSV O60911 1/20 0.43
CTSL P07711 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8618250 1.00 MAOB (0.52) MAOBGSTP1S1PR1S1PR3PARP15
SCHEMBL8613447 0.95 MAOB (0.55) MAOBGSTP1S1PR1S1PR3PARP15
SCHEMBL8615440 0.93 GSTP1 (0.55) MAOBGSTP1S1PR1S1PR3MCL1
SCHEMBL8616016 0.93 GSTP1 (0.54) MAOBGSTP1S1PR1S1PR3PARP15
SCHEMBL8613086 0.93 MAOB (0.59) MAOBGSTP1PARP15PARP10MAOA
SCHEMBL8613938 0.92 GSTP1 (0.52) MAOBGSTP1S1PR1S1PR3PARP15
SCHEMBL8642277 0.91 MAOB (0.51) MAOBGSTP1S1PR1S1PR3PARP15
SCHEMBL8612484 0.91 GSTP1 (0.51) MAOBGSTP1MCL1PTGES
SCHEMBL8617339 0.91 GSTP1 (0.57) MAOBGSTP1S1PR1S1PR3MAOA
SCHEMBL8617910 0.89 GSTP1 (0.56) MAOBGSTP1S1PR1S1PR3MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665836-B1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AG (DE) 1998-04-29 EP disclosed
EP-0665836-A1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1995-08-09 EP disclosed
WO-1994010152-A1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1994-05-11 WO disclosed