Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | QPCT | Q16769 | 2/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619788 | 1.00 | HDAC3 (0.35) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL8619800 | 1.00 | HDAC3 (0.35) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL7361549 | 0.83 | TACR3 (0.40) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL7361551 | 0.83 | TACR3 (0.40) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL8620009 | 0.83 | QPCT (0.39) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL8622425 | 0.83 | QPCT (0.39) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL7424824 | 0.83 | QPCT (0.39) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL7353557 | 0.82 | QPCT (0.38) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL7353564 | 0.82 | QPCT (0.38) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL7354758 | 0.82 | QPCT (0.38) | HDAC3HDAC4HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |