Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 8/20 | 0.77 |
| ▸ | FNTB | P49356 | 8/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | SQLE | Q14534 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11049165 | 1.00 | FNTA (0.77) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL10669823 | 1.00 | FNTA (0.77) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL11049186 | 1.00 | FNTA (0.77) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL11619634 | 1.00 | FNTA (0.77) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL1395164 | 0.98 | FNTA (0.73) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL3959523 | 0.90 | FNTA (0.68) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL3959518 | 0.90 | FNTA (0.68) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL584890 | 0.89 | FNTA (0.67) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL1716802 | 0.89 | FNTA (0.67) | FNTAFNTBKMT2AKDM4EATM | |
| SCHEMBL584888 | 0.89 | FNTA (0.67) | FNTAFNTBKMT2AKDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |