Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 6/20 | 0.75 |
| ▸ | HEXB | P07686 | 6/20 | 0.75 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | AHR | P35869 | 1/20 | 0.71 |
| ▸ | RAD52 | P43351 | 1/20 | 0.71 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.71 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.57 |
| ▸ | OGA | O60502 | 1/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28976576 | 0.95 | HEXA (0.82) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL3292136 | 0.93 | LCK (0.68) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL10396110 | 0.92 | POLB (0.83) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL12672650 | 0.91 | LCK (0.65) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL12660257 | 0.90 | HEXA (0.61) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL14463932 | 0.90 | LCK (0.64) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL12672841 | 0.89 | LCK (0.66) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL14525135 | 0.89 | HEXA (0.60) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL28976570 | 0.88 | HEXA (0.71) | HEXAHEXBPOLBNR1I2AHR | |
| SCHEMBL12660389 | 0.88 | HEXA (0.63) | HEXAHEXBPOLBNR1I2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947839-B2 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20070134243-A1 | Antibody drug conjugates and methods | GENENTECH, INC. | 2007-06-14 | — | — | US | disclosed |
| EP-0714387-B1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AG (DE) | 1998-05-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070134243-A1 | Antibody drug conjugates and methods | BOD1L1, MKI67, CCNI | HEXA 3422/4885HEXB 3477/4885POLB 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.