SCHEMBL8621032

SCHEMBL8621032

CCCCCCCCCCCCCCCCCC(=O)NCCCSc1ccccn1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.58
CYP1A2 P05177 1/20 0.51
CYP2C19 P33261 1/20 0.51
ALDH1A1 P00352 4/20 0.50
SMN1; SMN2 Q16637 5/20 0.49
NPC1 O15118 4/20 0.49
RAB9A P51151 4/20 0.49
FAAH O00519 1/20 0.49
ALOX12 P18054 1/20 0.48
EPHX2 P34913 2/20 0.48
LMNA P02545 2/20 0.47
HTT P42858 1/20 0.47
MAPT P10636 2/20 0.47
KMT2A Q03164 1/20 0.47
MTNR1A P48039 1/20 0.46
TP53 P04637 1/20 0.46
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8613529 1.00 HPGD (0.58) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL8616688 1.00 HPGD (0.58) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL8621478 1.00 HPGD (0.58) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL8615172 1.00 HPGD (0.58) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL9036946 1.00 HPGD (0.58) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL8619539 0.99 HPGD (0.59) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL8616296 0.96 HPGD (0.57) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL8619397 0.96 HPGD (0.57) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL8615235 0.93 EPHX2 (0.58) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL8615231 0.93 EPHX2 (0.58) HPGDCYP1A2CYP2C19ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5767121-A ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-06-16 US disclosed