Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SCN2B | O60939 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL831763 | 0.94 | CYP2C8 (0.40) | KMT2ACYP2C8PTGDR2SCN2BSCN1A | |
| SCHEMBL831674 | 0.92 | CYP2C8 (0.43) | KMT2ACYP2C8PTGDR2ALDH1A1MAPT | |
| SCHEMBL831406 | 0.92 | CYP2C8 (0.43) | KMT2ACYP2C8PTGDR2ALDH1A1MAPT | |
| SCHEMBL831822 | 0.92 | CYP2C8 (0.45) | KMT2ACYP2C8MCHR1ALDH1A1SCN5A | |
| SCHEMBL832077 | 0.91 | KMT2A (0.38) | KMT2ACYP2C8PTGDR2MCHR1ALDH1A1 | |
| SCHEMBL831751 | 0.91 | CYP2C8 (0.41) | KMT2ACYP2C8PTGDR2ALDH1A1MAPT | |
| SCHEMBL831050 | 0.91 | SCN9A (0.41) | KMT2ACYP2C8SCN2BSCN1ASCN1B | |
| SCHEMBL832184 | 0.90 | CYP2C8 (0.40) | KMT2ACYP2C8ALDH1A1SCN2BSCN1A | |
| SCHEMBL831968 | 0.90 | CYP2C8 (0.40) | KMT2ACYP2C8SCN5ASCN9AMEN1 | |
| SCHEMBL10257265 | 0.90 | CYP2C8 (0.41) | KMT2ACYP2C8PTGDR2MAPTSCN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | KMT2A 321/4885CYP2C8 847/4885PTGDR2 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.