Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | FNTA | P49354 | 1/20 | 0.58 |
| ▸ | FNTB | P49356 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.53 |
| ▸ | SQLE | Q14534 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626304 | 0.85 | KMT2A (0.55) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL8619405 | 0.82 | KMT2A (0.61) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL8850354 | 0.80 | KMT2A (0.64) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL8620659 | 0.79 | SQLE (0.60) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL18897542 | 0.78 | KMT2A (0.67) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL9304569 | 0.77 | KMT2A (0.73) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL4572068 | 0.77 | KMT2A (0.73) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL21631709 | 0.77 | KMT2A (0.73) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL21631695 | 0.77 | KMT2A (0.73) | KMT2AFNTAFNTBMAPTMEN1 | |
| SCHEMBL28891248 | 0.77 | KMT2A (0.73) | KMT2AFNTAFNTBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |