Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | PARG | Q86W56 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL832363 | 0.84 | CYP2C8 (0.38) | KMT2AGRIN1GRIN2BPARGOPRM1 | |
| SCHEMBL831901 | 0.77 | CYP2C8 (0.38) | KMT2AGRIN1GRIN2BPARGDDR1 | |
| SCHEMBL832478 | 0.74 | CYP2C8 (0.43) | KMT2AGRIN1GRIN2BPARGDDR1 | |
| SCHEMBL12673730 | 0.73 | CYP2C8 (0.53) | KMT2AGRIN1GRIN2BEPHX2CYP2C8 | |
| SCHEMBL831141 | 0.72 | PPARG (0.41) | KMT2AGRIN1GRIN2BDDR1EPHX2 | |
| SCHEMBL10256535 | 0.72 | KMT2A (0.48) | KMT2AGRIN1GRIN2BDDR1EPHX2 | |
| SCHEMBL831415 | 0.71 | PPARG (0.46) | KMT2AGRIN1GRIN2BDDR1EPHX2 | |
| SCHEMBL831591 | 0.71 | CYP2C8 (0.39) | KMT2AGRIN1GRIN2BDDR1EPHX2 | |
| SCHEMBL830972 | 0.71 | CYP2C8 (0.42) | KMT2AGRIN1GRIN2BPARGDDR1 | |
| SCHEMBL831451 | 0.71 | CYP2C8 (0.37) | KMT2AGRIN1GRIN2BPARGDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | KMT2A 321/4885GRIN1 2446/4885GRIN2B 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.